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The finding suggested that the oxidative damage in cells exposed to SiO 2 NPs was more serious than that in A549 cells exposed to microsized SiO 2 [150]

doi: 10.1016/j.semcdb.2008.12.013

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Molecular Targets of Oxidative Stress Although the physiological level of ROS is crucial for governing life processes through redox signaling, when ROS production exceeds the regulatory limits of the antioxidant system, excessive ROS can contribute to the oxidative damage of biomolecules, including nucleic acids, proteins, and lipids